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Description
IL-6 Protein, RatProduct Specification Species Rat Synonyms Interleukin 6, IL 6 Accession P20607 Amino Acid Sequence Phe25 Thr211 Expression System E. coli Molecular Weight 20 22 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 20mM NaAc, 300mM NaCl, pH5. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Rat |
| Synonyms | Interleukin-6, IL-6 |
| Accession | P20607 |
| Amino Acid Sequence | Phe25-Thr211 |
| Expression System | E.coli |
| Molecular Weight | 20-22 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20mM NaAc, 300mM NaCl, pH5.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Semin Immunol. 2014 Feb;26(1):2-12. |
Background
Rat Interleukin-6 (IL-6) is a pleiotropic cytokine encoded by the Il6 gene on chromosome 4 (NC_086022.1, 5889999..5894575, complement), consisting of 5 exons that produce a protein-coding transcript . As a key member of the IL-6 family, it orchestrates acute-phase responses, immune regulation, and metabolic homeostasis in rodents. Signals through two distinct pathways in rats: Classic signaling: IL-6 binds membrane-bound IL-6Rα, recruiting gp130 to activate JAK1/STAT3 cascade; Trans-signaling: Soluble IL-6Rα (sIL-6R) complexes with IL-6 to activate gp130 on cells lacking membrane IL-6Rα, amplifying inflammatory responses in neurons and vascular tissue.
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