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Description
Beta IV Tubulin Recombinant Rabbit mAb (S-1572-30)Product Specification Host Rabbit Antigen Beta IV Tubulin Synonyms Tubulin beta 4A chain; Tubulin 5 beta; Tubulin beta 4 chain; TUBB4; TUBB5; TUBB4A Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P04350 Clone Number S 1572 30 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, K562, Jurkat, U 2 OS, mouse brain, mouse spleen, mouse kidney, C6, rat brain Purification
Product Specification
| Host | Rabbit |
| Antigen | Beta IV Tubulin |
| Synonyms | Tubulin beta-4A chain; Tubulin 5 beta; Tubulin beta-4 chain; TUBB4; TUBB5; TUBB4A |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P04350 |
| Clone Number | S-1572-30 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, K562, Jurkat, U-2 OS, mouse brain, mouse spleen, mouse kidney, C6, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:20000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Beta IV Tubulin is a member of the beta tubulin family, encoded by the TUBB4A gene, and is primarily involved in the formation of microtubules, which are essential components of the cytoskeleton. It plays a critical role in cellular functions such as maintaining cell shape, facilitating intracellular transport, and enabling cell division. Beta IV Tubulin is selectively expressed in oligodendrocytes in the central nervous system, where it helps transport myelin proteins, lipids, and RNA during myelination. Additionally, it is required for the proper structure and function of cilia in various tissues, including the trachea, ependyma, and testis. Mutations in the TUBB4A gene can lead to neurological disorders such as hypomyelinating leukodystrophy and dystonia.
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