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Description
Merlin Recombinant Rabbit mAb (S-2331-22)Product Specification Host Rabbit Antigen Merlin Synonyms Moesin ezrin radixin like protein; Neurofibromin 2; Schwannomerlin; Schwannomin; SCH; NF2 Immunogen Synthetic Peptide Location Nucleus, Cell projection Accession P35240 Clone Number S 2331 22 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, PC 3, MCF7, HepG2, MEF, mouse brain, rat brain Predicted Reactivity Bb Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Merlin |
| Synonyms | Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; SCH; NF2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Cell projection |
| Accession | P35240 |
| Clone Number | S-2331-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, PC-3, MCF7, HepG2, MEF, mouse brain, rat brain |
| Predicted Reactivity | Bb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, AfGrMk |
Background
Merlin protein, also known as neurofibromin 2 (NF2), is a crucial tumor suppressor protein encoded by the NF2 gene. It plays a vital role in regulating cell proliferation, differentiation, and apoptosis. Merlin acts as a negative regulator of the Hippo signaling pathway, which is essential for controlling organ size and cell fate determination. When functioning normally, Merlin helps to inhibit the overgrowth of cells and prevents the formation of tumors. Mutations in the NF2 gene that lead to a loss of functional Merlin protein are associated with the development of various types of cancer, including schwannomas, meningiomas, and mesotheliomas. In addition to its role in cancer, Merlin is also involved in the regulation of cell adhesion and the maintenance of cellular architecture. Ongoing research is focused on understanding the detailed mechanisms of Merlin's action and exploring potential therapeutic strategies targeting the Merlin-Hippo pathway for cancer treatment.
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4.6 ★★★★★
Based on 1627 reviews
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Product Reviews
★★★★★ 5
Quilt
Color: White, Size: Queen
It’s a nice thin quilt for the warmer months.
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Cooling
Color: Dark Gray Pinstripe, Size: King(108"x90")
Very lightweight & cooling!
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Cool, lightweight, and surprisingly comfortable!
I absolutely love this cooling comforter! The first thing I noticed is how lightweight it is. It comes in at just over 3 pounds, so it’s not thick or bulky at all, which I really appreciate. It feels easy to move around and doesn’t weigh you down while you’re sleeping.
I chose the queen size in dark gray. It’s reversible, which is such a nice bonus. One side has a simple white stripe pattern that gives it a little personality, and the other side is a solid gray. The solid gray side is the cooling side, and oh my goodness, it feels so silky and smooth to the touch. That cool-to-the-touch feeling is really noticeable when you first get under it.
I didn’t have any issues with it sliding off the bed, but I’ll mention that I don’t toss and turn a lot at night, so that may be part of it. If you’re someone who moves around more, your experience might be a little different.
As far as washing goes, I did notice a small inconsistency. The product description recommends hanging it to dry, but the tag on the comforter says it can be machine washed and dried. I’m going to go ahead and follow the tag instructions and tumble dry it. I’ll definitely come back and update if I notice any issues after machine drying it.
I live in the South and right now our weather is actually pretty mild so it’s a little hard to say just how much of the cooling effect is from the blanket versus the temperature in the house. That said, I do feel like it’s helping. I haven’t been waking up hot and the fabric itself definitely feels cool and breathable so I’m excited to see how it performs when the real heat kicks in.
I’m also really pleased with the overall quality. The stitching looks clean, there are no loose threads and everything feels well made and thoughtfully put together. It gives me confidence that it will hold up nicely over time.
This doesn’t affect my rating, but I do wish there were more color or pattern options to choose from. It would be fun to have a few more styles, especially since it’s such a nice-looking comforter.
5 stars for its lightweight feel, silky cooling fabric, and solid, well-made construction.
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Reviewed in the United States on April 9, 2026
★★★★★ 5
This is a great blanket for those who prefer to be cool all night.
This is a great blanket for those who prefer to be slightly cooler all night. I have been using this for almost two months now. It's been difficult to figure out how to explain it's use. Ultimately I have figured out that it acts like a blanket, insulating and keeping you warm, however, wherever the blanket is actually resting on your skin stays cool. It took me a while to figure it out. How does an insulating blanket cool you? I'm not sure how the material actually works, but that is what it does, at least for slightly cool interior weather with a bit of humidity. I imagine in the desert it may work differently. I would say nights when a sheet may be too cold or thin, and a blanket way too hot, this is the in between.
The material itself is soft and almost silky. It is made well, has a pleasant appearance on the bed, and doesn't wrinkle. So getting up in the morning it is easy to toss and make the bed. It breathes unlike a duvet cover and feather blanket, so no need to air it out so much.
I have come to really love it and recommend it for anyone looking for an in between, between a sheet and comforter. I have never woken up sweating or pulling it off at night. My only experience was at first thinking I was cold but learning that I was not, only where my skin was in contact!
For the quality and price, it is definitely worth giving it a try!
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Reviewed in the United States on April 25, 2026
★★★★★ 5
Attractive Comforter That Will Keep Hot Sleepers Cool
The Bedsmile striped cooling comforter ice blanket for hot sleepers is amazing. It's cool and comfortable thanks to its unique structure. If you're a hot sleeper, then this comforter is definitely the one for you.
This comforter gives you the comfort of a blanket, but manages to also keep you cool throughout the night. It's soft and it feels cold to the touch on one side and smooth and comforting on the other. This is because one side is made from nylon which feels cool because it's a synthetic, thermally conductive material that quickly draw heat away from your skin. My daughter is the lucky recipient of this comforter, and she loves it. It matches perfectly with the gray sheets and pillowcases she already has.
I have to admit I had my doubts when I first pulled it out of the package and saw it wasn't thick like a traditional comforter, but so far it has exceeded my expectations. The design is very attractive, gray with white stripes on one side, and a solid gray on the other. It is the solid gray side that is made of nylon for that cooling effect.
It’s lightweight without feeling flimsy, and it is well-stitched. This is a quality comforter made with top of the line material. It's Queen size and its measurements are true. The ad says it is "reversible" but the solid gray side is nylon and that is where you get the cooling benefits...plus, it looks so much better with the gray and white strips on top.
I'm really happy with this bedspread, it looks great, it is made with quality materials, it is soft and silky and it does keep you cool and comfortable at night. If you're looking for a good nights sleep, I highly recommend this comforter.
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Reviewed in the United States on March 19, 2026
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